The cast of Ugly Betty has partnered with the United Nations to shed light on a campaign to stop the spread of malaria — a major killer of child in Africa.

ABC’s award-winning dramedy became the first comedy shot inside the UN’s New York City headquarters when the cast lined up for a special malaria-themed episode, which will kick off the fourth season of Ugly Betty next Friday night.

The season opener will feature the UN’s Nothing But Nets Initiative, a campaign revealing the role mosquito nets play in preventing the disease.