Besieged by a myriad of medical issues, tech genius Steve Jobs has stepped down as CEO of Apple Inc. Jobs relinquished the reins of the world’s largest technology corporation to right-hand man and longtime No. 2 Tim Cook on Wednesday, ending a 14 year tenure in command at a company he brought back from the brink of financial disaster in the ’90s.

Cancer-stricken Jobs, who has been on medical leave from the company since Jan. 17, says he can “no longer meet” the duties and expectations of the job. A gaunt Steve — who underwent a liver transplant two years ago — was last seen publicly in March, during the San Francisco unveiling of Apple’s hugely-popular iPad 2.

“I have always said if there ever came a day when I could no longer meet my duties and expectations as Apple’s CEO, I would be the first to let you know. Unfortunately, that day has come,” he said in a brief letter announcing his resignation shortly after 6:40 PM ET.

The ex-Apple boss was diagnosed with a rare form of pancreatic cancer in 2004. He’s since undergone a series of aggressive treatments aimed at beating the disease. He’s survived longer than most with a similar diagnosis, but Wednesday’s resignation signals that his disease — kept in check for more than seven years — is advancing beyond doctors’ control, experts tell USA TODAY.

The paper writes: “Jobs suffers from a pancreatic neuroendocrine tumor, which accounts for only about 5% of the 43,000 pancreatic cancers diagnosed each year, and is generally more curable than more common types of pancreatic cancer, says Margaret Tempero, a pancreatic cancer expert at the University of California-San Francisco.”

A college dropout, Jobs started Apple Computer with friend Steve Wozniak in the Jobs family garage in Silicon Valley in the late 1970s.

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“His health clearly wasn’t improving and there was going to come a time when he was going to have to step aside,” tech analyst Rob Enderle tells MSNBC. “Apple was designed around Steve Jobs, so there was really never going to be a great time for this.”

What do you think of Steve Jobs’ decision to step down as head of Apple? Are you sorry to see him go?