PEOPLE Magazine released its annual “Most Beautiful” issue on Wednesday, which features 100 of the most striking faces from the worlds of film, television, music, and politics.

Christina Applegate graces the cover of this year’s “Most Beautiful” issue. The star of ABC’s Samantha Who? underwent reconstructive breast surgery last November after being diagnosed with breast cancer — a diagnosis the actress credits with giving her a new lease on life.

“I used to be really shy but I started to come into my own in my late 20s and early 30s. Now I’m not afraid to speak up in a room full of people and be a part of the conversation.”

Vanessa Hudgens, Freida Pinto, America Ferrera, and Robert Pattinson are also featured on this year’s “Most Beautiful” list.