Oprah Winfrey and Ellen DeGeneres will make talk show history when Oprah appears on Ellen DeGeneres for the first time, in an episode airing Thursday, February 22.

Episode Highlights Include:

Oprah announces that she is backing Barack Obama over Hillary Clinton for the Democratic presidential nomination: “It’s tough… I’m just feeling Barack.”

The two talk hosts reveal how they discovered they were neighbors – Oprah: “Stedman was at the corner deli… He said he ran into you and Portia (de Rossi) there.”

Ellen: “There was a long, long line, and he’s only buying a tiny brownie, and he was already eating it, and I thought: ‘Oprah, cook for him! What’s wrong with you?’” And Ellen gives Oprah a set of spare keys to her house!