“Call me, Kate!” File this under “Unlikely Couples.”

We hear Mario Lopez has the hots for the Original Reality Octomom, Kate Gosselin! According to a scoop featured in the Nov. 23 issue of GLOBE, the notorious womanizer was spotted flashing his double dimples at the soon-to-be divorcee as the pair laughed and chatted at the 2009 California Women’s Conference in Long Beach last month.

Kate, who joined Alicia Keys, Geena Davis, and Valerie Bertinelli, as a featured speaker at this year’s event, was shocked when Saved By The Bell’s A.C. Slater approached the Jon & Kate Plus 8 star for a bit of “friendly” conversation. And boy was Mario laying it on thick. One spywitness overhead the hunk telling Kate that “she was much prettier in person” before adding that “he was so excited to meet her.”

GLOBE writes: “The hunky Extra host was also seen slipping Kate, 34, his number, telling her to give him a call.”

Mario was briefly married to actress Ali Landry and later dated his former Dancing With The Stars partner, the sexy Karina Smirnoff. Both romances ended after Mario cheated.