Rumors of marital problems, a tell-little book from her estranged younger brother, and accusations of a tawdry affair-and sex tape-with Yankees star Alex Rodriguez have Madonna headed for a complete physical and emotional breakdown, a new tabloid report spills.

The stressed pop queen is so distraught by all the bad press she’s been receiving doctors recently diagnosed her with anemia-subjecting the multiplatinum-selling star to “blood analysis done every few days.”

“Madonna is doing less than okay,” a tattling spy told The Sun Monday. “She’s down physically and mentally. The situation with Guy is very, very tense. The way the press are going crazy with the A-Rod story, her brother’s book and her physical exhaustion are all taking their toll.”

“She feels nobody has taken her side. One of her closest pals says she has never seen Madonna so low.”

Doctors have ordered Madonna to take it easy as the Material Girl’s health becomes increasingly fragile; and that could spell trouble for the star’s top-selling Sticky & Sweet Tour, which kicks off next month.

“Madonna was told to go soft on work and rehearsals, so she will now take one proper day off every week and go easy in the mornings…She has been rehearsing for the tour and she is totally miserable. She has been feeling low and looking really gaunt…”