Lisa Kudrow and Courteney Cox are in for a very “un-Friend-ly” reunion on ABC’s sex-charged freshman comedy, Cougar Town.

The former co-stars get back together again when Lisa guest-stars as a mean-spirited dermatologist on an upcoming episode of Courteney’s hit new sitcom.

“They didn’t want to play friends,” executive producer Bill Lawrence told Entertainment Weekly’s Michael Ausiello. “[Lisa] plays a dermatologist who is a horrible, horrible person, but [Courteney] goes to her because she’s the best.The [sight] of them playing people who dislike each other intensely was very funny for me to watch.”

Lisa’s Cougar Town episode is expected to air early next year.