Dario Alequin/INFphoto.com
Has John Mayer dumped Jennifer Aniston for the second time?

E! spies sure seem to think so.

Celebrity insiders tell E! gossip columnist Marc Malkin that Jenn and John are officially dunzo after therock star booted Friends actress, for the second time in their 12-month romance, shortly after she returned to Hollywood following her European promotional tour the hit film Marley & Me.

“He broke up with her when she got back from her European tour,” says a source.