E!’s First Lady of Late Night, Chelsea Handler, took on Katie Price — Britain’s answer to Paris Hilton — on Thursday’s Chelsea Lately.

Newlyweds Lamar Odom, of the Los Angeles Lakers, and socialite Khloe Kardashian sat down for a knee-slapping chat on love, babies, and their quickie wedding with E!’s First Lady of Late Night, Chelsea Handler.

The couple was on to promote their Keeping Up With The Kardashians’ Wedding Special, airing this Sunday on E!.

Chelsea Handler has never been one to mince words, and she isn’t starting now. It appears the razor-tongued comedienne has no sympathy for celebrities she routinely mocks on her late night E! series, Chelsea Lately.

“I think the people I talk about are generally so stupid [that] they don’t even know I’m saying bad things about them,” Chelsea told Philadelphia Style Magazine this week. “I’ve run into Paris Hilton and she’s like, ‘Oh, I love your show.’ And I’m like, ‘You can’t love my show if you can hear,’” she added.

Leggy blonde Chelsea Handler is Playboy Magazine’s newest bunny.

On The Jay Leno Show Wednesday night (Click Here For The Video!), the acid-tongued meanie showed off her cover on the magazine’s December 2009 holiday issue, where she appears in a tiny gold bikini.

Sorry guys, you’ll be disappointed to learn that Chelsea won’t be getting naked to show you why her milkshake brought all the boys to the yard — at least not in this issue. The inside photo features the hostess of E!’s Chelsea Lately covered up by an apron and mini dress while preparing a vodka-soaked Christmas meal with her sidekick Chuy.

On The Jay Leno Show, Jay surprised acid-tongued comedienne Chelsea Handler with a life-size replica of her image on the cover of the December issue of Playboy Magazine.

The tough-talking author and talk-show host says she gave up drinking “for about a day and a half” as she prepared for her debut pictorial in the iconic men’s mag. Chelsea’s male fans may be a little disappointed. The inside photo features the star covered up by an apron and mini dress while preparing a vodka-soaked Christmas meal with her sidekick Chuy.

The Lamas bring the drama to Chelsea Lately.

Jennifer Aniston’s Love Happens promo tour brought her to the stage of E!’s Lady of Late Night, Chelsea Handler, on Thursday. Here’s a video of Jenn’s appearance on Chelsea Lately on Sept. 17.

Now that Dancing With The Stars cutie Karina Smirnoff has dismissed series co-star/rebound guy Maksim from the ballroom, do you think her Season 9 partner Aaron Carter stands a shot at love with the petite dancer?

Chelsea Handler sure does!

“Backstreet’s back….” Before those pesky N’Syncers came along, was there a hotter boy band of the late ’90s than Orlando’s own Backstreet Boys?

The guys are hitting the promo circuit in support of their latest album, This Is Us, and Tuesday night’s stop brought the group to the set of E!’s late night comedy Chelsea Lately.

Here’s the video, in case you missed it.

Kourtney & Khloe Kardashian promote Sunday night’s season premiere of Kourtney & Khloé Take Miami in an interview with E!’s Chelsea Handler on Tuesday.