Based on the, to some minds, corny 1950s Vincent Price movie, the 1986 version is the classic example of a remake blowing the original out of the maggot-infested water. Jeff Goldblum gives his best performance in the new version as the scientist, Seth Brundle, whose teleportation experiment goes very, very wrong, merging his DNA with that of an insect. Rather than swapping body parts with the insect, as in the original, the effect is to gradually transform him into a giant fly. Visionary director David Cronenberg throws in tons of disturbing imagery, with the human/fly hybrid's body gradually disintegrating until it comes to resemble Michael Jackson in his South Park appearance.
The movie has appeared on various "best movie" lists, won multiple awards, and was even made into a successful opera in 2008. Now that's a remake!